Table 2Comparison of Probe ML407 to selected Prior Art Compounds

Image ml407fu1.jpg
PropertyStaurosporineOSU-03012ML407
Adenylate Kinase IC50 (μM)Non-specific cell death5.00.595
Ratio of {IC50 (sorbitol +)/IC50 (sorbitol-}1.01.221.8
Cellular Toxicity in HEK293 IC50 (μM)7.794.39>80

From: Discovery and Evaluation of Fungicidal Anti-Cryptococcal Molecules

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Probe Reports from the NIH Molecular Libraries Program [Internet].
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