Bacteria are made up of just one cell

Bacteria are single-cell organisms. Some bacteria need oxygen to survive and others do not. Some love the heat, while others prefer a cold environment. Well-known examples of bacteria include salmonella and staphylococcus bacteria.

Most bacteria aren't dangerous for humans. Many of them even live on or in our body and help us to stay healthy. For instance, lactic acid bacteria in the bowel help us to digest food. Other bacteria help the immune system by fighting germs. Some bacteria are also needed in order to produce certain types of food, like yogurt, sauerkraut or cheese.

Less than 1% of all bacteria cause diseases – but this is just a rough estimate because there are no exact numbers. Tuberculosis, for instance, is caused by bacteria. Bacterial infections can be treated with antibiotics. These are medicines that kill the bacteria or at least stop them from multiplying.

Many other infections – including diarrhea, colds or tonsillitis – can also be caused by bacteria, but they are usually caused by viruses. Antibiotics aren't effective against viruses. So it's not a good idea to start using antibiotics too soon if you're not sure that it's a bacterial infection.

Viruses invade healthy cells and make us ill

Unlike bacteria, viruses have no cells of their own. This means that they're not, strictly speaking, living organisms. Instead, they're made up of one or more molecules surrounded by a protein shell. The genetic information found inside this shell is needed for the viruses to reproduce.

Many viruses cause diseases. Some are harmless and only lead to a minor cold, while others can cause serious diseases like AIDS. Other diseases caused by viruses include COVID-19, influenza ("the flu"), measles and inflammation of the liver (viral hepatitis).

Viruses invade healthy cells and start to multiply from these cells. A virus can't reproduce without these host cells. Not all viruses cause symptoms, and in many cases the body successfully fights back against the attackers. This is the case with cold sore viruses, which many people become infected with at some point. These viruses lie inactive in certain nerve cells. In some people they lead to the typical lip sores when their immune system is weak or run-down.

It is quite difficult to fight viruses with medication. To protect against some viruses, the immune system can be “trained” by a vaccination so that the body is better prepared to fight the virus.

Fungi are widespread

Fungi can live in lots of different environments. The best-known fungi include yeast, mold and edible fungi like mushrooms. Just like bacteria, some fungi occur naturally on the skin or in the body. But fungi can also cause diseases.

Diseases caused by fungi are called mycoses. Common examples include athlete’s foot or fungal infections of the nails. Fungal infections can sometimes also cause inflammations of the lungs, or of mucous membranes in the mouth or on the reproductive organs. These can become life-threatening in people who have a weakened immune system.

But some fungi can also help to fight diseases. For example, one type of mold naturally produces the antibiotic penicillin, which fights bacteria.

Sources

• Andreae S, Avelini P, Berg M et al. Lexikon der Krankheiten und Untersuchungen. Stuttgart: Thieme; 2008.
• Brandes R, Lang F, Schmidt R. Physiologie des Menschen: mit Pathophysiologie. Berlin: Springer; 2019.
• Kasper DL, Fauci AS, Hauser SL et al. Harrison's Principles of Internal Medicine. New York: McGraw-Hill; 2015.
• National Institute of Allergy and Infectious Diseases (NIAID). Understanding Microbes in Sickness and in Health. NIH Publication No. 09-4941. 2006.
• Pschyrembel Online. 2021.

• IQWiG health information is written with the aim of helping people understand the advantages and disadvantages of the main treatment options and health care services.

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