Table 4

Causes of Drug Associated Thyrotoxicosis

DrugMechanismTimingTherapy
AmiodaroneIodine (AIT 1)months to yearsSupportive, ATDs, Perchlorate, Surgery
AmiodaroneThyroiditis (AIT 2)Often > 1 yearSupportive care, Surgery, Prednisone
LithiumThyroiditisOften > 1 yearATDs, Supportive
Interferon-αThyroiditis or Graves’MonthsSupportive, ATDs, and /or 131-I (Graves’ only)
Interleukin-2Thyroiditis or Graves’MonthsSupportive, ATDs, and /or 131-I (Graves’ only)
Contrast (I)Thyroid autonomyWeeks to monthsATDs
131-I AblationDestructive thyroiditis1-4 weeksSupportive, prednisone
131-I Rx of TMNGGraves’ disease3-6 months131-I, surgery, ATDs
ATD= Anti thyroid drugs, TMNG= Toxic Multinodular Goiter

From: Subacute Thyroiditis

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