Table 4.

PINK1 Type of Young-Onset Parkinson Disease: Recommended Evaluations Following Initial Diagnosis

System/ConcernEvaluationComment
Neurologic Detailed neurologic exam focusing on presence & extent of movement disorderUsing the Unified Parkinson Disease Rating Scale 1
Assessment for presence/severity of atypical manifestations
Eval by PT, OT, & SLP if required
Autonomic Assessment for presence/severity of urinary urgency, urge incontinence, constipation, & orthostatic hypotension
Neuropsychiatric Formal neuropsychiatric assessment w/neuropsychiatrist
Cognition Formal cognitive testing
Sleep Assessment for presence/severity of sleep disturbances, e.g., difficulties falling asleep, staying asleep, or rapid eye movement sleep behavior disorder (RBD)Consider polysomnography for persons w/suspected RBD.
Smell Assessment for presence/severity of hyposmia
Nutrition/
Gastrointestinal
  • Nutritional eval by dietician to monitor & ensure adequate caloric intake
  • SLP assessment of safety of feeding
Genetic counseling By genetics professionals 2To inform affected persons & their families re nature, MOI, & implications of PINK1 type of young-onset Parkinson disease to facilitate medical & personal decision making
Family support
& resources 		By clinicians, wider care team, & family support organizationsAssessment of family & social structure to determine need for:

MOI = mode of inheritance; OT = occupational therapist; PT = physical therapist; SLP = speech-language therapist

1.

Goetz et al2008]

2.

Medical geneticist, certified genetic counselor, certified advanced genetic nurse

From: PINK1 Type of Young-Onset Parkinson Disease

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