Table 4.6

Pharmacokinetics: Comparisons between new and important old AEDs.

Drug-drug interactions
AED Oral absorptionDosingKineticsMetabolisnAffected by othersAffects others% of perfect score
Carbamazepine33211161
Gabapentin31–2233386
Lamotrigine33211267
Levetiracetam33323394
Phenytoin33111156
Tiagabine22312161
Topiramate23331172
Valproate33212167
Vigabatrin33333294

From Patsalos 101 with the permission of the author and the Editor of Pharmacology & Therapeutics

From: Chapter 4, Principles of Therapy in Epilepsies

Cover of The Epilepsies
The Epilepsies: Seizures, Syndromes and Management.
Panayiotopoulos CP.
Oxfordshire (UK): Bladon Medical Publishing; 2005.
Copyright © 2005, Bladon Medical Publishing, an imprint of Springer Science+Business Media.

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