Table 3Overview of published literature (n=17 studiesa), with number of metastatic breast cancer patients (n=557)

Bone Scan (n=3 studies; 123 patients)MRI (n=4 studies; 130 patients)CT (n=7 studies; 206 patients)FDG-PET or FDG-PET/CT (n=10 studies; 454 patients)FLT-PET/CT (n=4 studies; 33 patients)F-FMISO PET/CT (n=1 study; 12 patients)FES-PET/CT (n=2 studies; 74 patients)Total (n=17 studies; 557 patients)
Study Population
 United States2
(n=76)		2
(n=61)		2
(n=76)		4
(n=279)		1
(n=14)		02
(n=74)		8
(n=273)
 Europe1
(n=47)		2
(n=69)		5
(n=130)		5
(n=163)		3
(n=19)		008
(n=272)
 Asia0001
(n=12)		01
(n=12)		01
(n=12)
Study Type
 Cohort (retrospective)2
(n=94)		1
(n=47)		2
(n=94)		6
(n=351)		002
(n=74)		7
(n=378)
 Cohort (prospective)1
(n=29)		3
(n=83)		5
(n=112)		4
(n=103)		4
(n=33)		1
(n=12)		010
(n=179)
 Randomized control trial00000000
Comparatorsb
 Tracer uptake vs. anatomic imaging2
(n=94)		3
(n=116)		6
(n=177)		4
(n=163)		3
(n=28)		01
(n=47)		7
(n=191)
 2 tracer uptakes0001
(n=12)		01
(n=12)		01
(n=12)
 Tracer uptake vs. biomarkers0002
(n=127)		2
(n=19)		004
(n=146)
 Bone scan vs. anatomic imaging1
(n=29)		01
(n=29)		00001
(n=29)
Outcomesc
 Tumor response3
(n=123)		3
(n=116)		7
(n=206)		10
(n=454)		4
(n=33)		1
(n=12)		2
(n=74)		16
(n=543)
 Progression-free survival1
(n=29)		01
(n=29)		3
(n=149)		0004
(n=178)
 Overall survival1
(n=76)		3
(n=83)		4
(n=145)		5
(n=240)		0005
(n=283)

CT = computed tomography; F-FMISO = F-fluoromisonidazole; FDG = fluorodeoxyglucose; FES = fluoroestradiol; FLT = fluorothymidine; MRI = magnetic resonance imaging; PET = positron emission tomography

a

Eight studies included greater than one type of imaging

b

Five studies did not include comparators of imaging

c

Some studies reported greater than one outcome

From: Findings

Cover of Imaging Techniques for Treatment Evaluation for Metastatic Breast Cancer
Imaging Techniques for Treatment Evaluation for Metastatic Breast Cancer [Internet].
Technical Briefs, No. 17.
Gold LS, Lee CI, Devine B, et al.
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