Interaction of H. pylori adhesins with host cell receptors. For simplicity, only the best studied H. pylori adhesin-receptor interactions are shown. The in vivo situation is likely much more complex, as described in the text, in that there may be dynamic and temporal expression of adhesins and receptors, and during any given time, H. pylori may interact with only a subset of the cellular receptors. (A) Interaction of H. pylori adhesins to gastric epithelial cell receptors. (B) Interaction of H. pylori adhesins to the basement membrane protein laminin. H. pylori has evolved multiple mechanisms to interact with host laminin.