| Species | Duration | NOAEL (mg/kg/d) | LOAEL (mg/kg/d) | Effect | Reference |
|---|---|---|---|---|---|
| Rat | 3-12 wk | None | 0.84 | Fibrosis, inflammation, large foci in renal cortex | Magos and Butler 1972 |
| Rat | 12 wk | 0.08 | Cytoplasmic masses in proximal tubules | Fowler 1972 | |
| Rat | 2 yr | 0.02 | 0.1 | Increased renal weights Decreased renal enzymes | Verschuuren et al. 1976 |
| Rat | 0-21 days of age | None | 1 | Altered renal function and renal hypertrophy | Slotkin et al. 1985 |
| Rat | 2 yr | 0.4 | Nephrosis | Solecki et al. 1991 | |
| Mouse | 26 wk | 0.15 | 0.6 | Degeneration of proximal tubules | Hirano et al. 1986 |
| Mouse | 0.03 (males) 0.13 (females) | 0.14 (males) 0.6 (females) | Chronic nephropathy, interstitial fibrosis | Mitsumori et al. 1990 | |
| Mouse | Once | 8 (males) 24 (females) | 16 (males) 32 (females) | Decreased phenolsulfonphthalein excretion, increased serum creatinine, swollen tubuler epithelium | Yasutake et at. 1991 |
From: 5, HEALTH EFFECTS OF METHYLMERCURY
NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.