| Prevalent protein context | |||||
|---|---|---|---|---|---|
| Domain | Occurrence in eukaryotes | Occurrence in prokaryotes | Eukaryotes | Prokaryotes | Functions in eukaryotes |
| WD40 | All | Ssp, Hi, Dr, Tm, Streptomyces, Cenarchium symbiosum (archaeon) | Multiple repeats in various regulatory proteins including G-protein subunits | Stand-alone, multiple repeats, Ser/Thr protein kinases | Various nuclear and cytoplasmic regulatory protein-protein interactions |
| Ankyrin | All | Ec, Ssp, Bb, Tp, Nm, Rp, Dr, Streptomyces | Multiple repeats in various cytoplasmic and regulatory proteins | Stand-alone, multiple repeats | Various forms of signal transduction including transcription regulation, cell cycle control and PCD |
| TIR | Animals, plants | Bs, Ssp, Streptomyces Rhizobium | Toll/Interleukin Receptors, PCD adaptors | Stand-alone, AP-ATPases, WD40 | Programmed cell death, interleukin signaling |
| EF-hand | All | Ssp, Streptomyces | Calmodulins, calcineurin phosphatase regulatory subunits, other Ca-binding proteins | Predicted Ca-binding proteins; transaldolase | Various forms of Ca-dependent regulation |
| FHA (Forkheadassociated) | All | Ct, Cp, Mtu, Ssp, Xf, Streptomyces, Myxococcus | Protein Ser/Thr kinases and phosphatase; various nuclear regulatory proteins | Stand-alone, adenylate cyclase, histidine kinase | Phosphoserine binding, protein kinase-mediated nuclear signaling |
| SET | All | Ct, Cp, Xf | Various multidomain chromatin proteins | Stand-alone | Histone methyltransferase |
| SWIB | All | Ct, Cp | SWI/SNF complex subunits | Stand-alone, Topoisomerase type I | Chromatin remodeling, transcription regulation |
| Sec7 | All | Rp | Guanine-nucleotide exchange factors; protein transport system components | Stand-alone (protein transport?) | Protein transport, GTPase regulation |
| Kelch | All | Ec, Hi, Af | Multiple repeats, fusions with POZ and other signaling domains; actin-binding proteins, transcription regulators | Stand-alone, multiple repeats | Transcription regulation; cytoskeleton assembly |
| Adenovirus-type protease | All; DNA-viruses | Ct, Ec | Stand-alone; ubiquitin-like protein hydrolases | Stand-alone; membrane- associated (Ct) | Regulation of ubiquitin- like-protein-dependent protein degradation |
| OTU-family protease | All; RNA-and DNA-viruses | Cp | Stand-alone or fused to ubiquitin hydrolase | Large protein with nonglobular domains | Unknown; possible role in ubiquitin-mediated protein degradation |
| START domains | Animals and plants | Pa | Stand-alone or fused to homeodomains and GTPase regulatory domains | Stand-alone | Lipid binding |
An update of the results presented in Reference 91.
From: Horizontal Gene Transfer in Prokaryotes: Quantification and Classification
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