| Cytogenic Abnormality | FAB Morphology | Median Age (years) | Approximate incidence in de novo AML | Prognostic Effect | Comments |
|---|---|---|---|---|---|
| t(8;21) | M2 | 30 | 5–7% | Favorable | Auer rods usually present |
| t(15;17) | M3 | 40 | 5–8% | Favorable | DIC† |
| abn 16q22 | M4 with eosinophilia | 35–40 | 5% | Favorable | High reinduction rate postrelapse |
| abn 11q23 | M5 | >50 | 3% | Poor | Hyperleukocytosis |
| +8 | Varied | >60 | 5–10% | Poor | — |
| del 5, del 7, 5q-7q-, or combinations | Varied; common in FAB M6 | >60 | 15–20% | Poor | Common in pts with 2o AML, MDS |
| inv 3 | Varied; increased platelet count | ? | <1% | Poor | Increased plt count; other abnormalities common (del 5, del 7) |
| +13 | Varied; sometimes undifferentiated | Probably >60 | 2% | Poor | Possible increased frequency of “hybrid” features |
| t(6;9) (p2;q34) | M2/M4 | ? | <1% | Poor | Prominent basophilia |
| t(9;22) | Usually M1 | Probably >50 | 1% | Poor | Splenomegaly |
DFS = disease-free survival.
DIC = disseminated intravascular coagulation.
From: Chapter 124, Acute Myeloid Leukemia in Adults
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