TABLE 9.1

Structures of O-glycan cores and antigenic epitopes found in mucins

O-GlycanStructure
Core
 Tn antigenGalNAcαSer/Thr
 Sialyl-Tn antigenSiaα2-6GalNAcαSer/Thr
 Core 1 or T antigenGalβ1-3GalNAcαSer/Thr
 Core 2GlcNAcβ1-6(Galβ1-3)GalNAcαSer/Thr
 Core 3GlcNAcβ1-3GalNAcαSer/Thr
 Core 4GlcNAcβ1-6(GlcNAcβ1-3)GalNAcαSer/Thr
 Core 5GalNAcα1-3GalNAcαSer/Thr
 Core 6GlcNAcβ1-6GalNAcαSer/Thr
 Core 7GalNAcα1-6GalNAcαSer/Thr
 Core 8Galα1-3GalNAcαSer/Thr
Epitope
 Blood groups O, HFucα1-2Gal-
 Blood group AGalNAcα1-3(Fucα1-2)Gal-
 Blood group BGalα1-3(Fucα1-2)Gal-
 Linear BGalα1-3Gal-
 Blood group iGalβ1-4GlcNAcβ1-3Gal-
 Blood group IGalβ1-4GlcNAcβ1-6(Galβ1-4GlcNAcβ1-3)Gal-
 Blood group Sd(a), CadGalNAcβ1-4(Siaα2-3)Gal-
 Blood group LewisaGalβ1-3(Fucα1-4)GlcNAc-
 Blood group LewisxGalβ1-4(Fucα1-3)GlcNAc-
 Blood group sialyl-LewisxSiaα2-3Galβ1-4(Fucα1-3)GlcNAc-
 Blood group LewisyFucα1-2Galβ1-4(Fucα1-3)GlcNAc-

From: Chapter 9, O-GalNAc Glycans

Cover of Essentials of Glycobiology
Essentials of Glycobiology. 2nd edition.
Varki A, Cummings RD, Esko JD, et al., editors.
Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2009.
Copyright © 2009, The Consortium of Glycobiology Editors, La Jolla, California.

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