Table 8, Further SAR elucidation Scaffold II – series E - Probe Reports from the NIH Molecular Libraries Program

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Entry	CID	SID	S/P	R₁	R₂	AML12 IC₅₀ (nM)^*
1E	9550710	103061845	P	Ph	benzo[d][1,3]dioxol-5-ylmethanamine	412
2E	49852482	104222755	S	H	(3,4-dimethoxyphenyl)methanamine	>10000
3E ML262	20855303	104222756	S	Ph	2-(3,4-diethoxyphenyl)ethanamine	6.39
4E	49852486	104222757	S	Ph	2-(3-ethoxy-4-methoxyphenyl)ethanamine	42.8
5E	20855299	104222758	S	Ph	2-(3,4-dimethoxyphenyl)ethanamine	186
6E	39969257	104222759	S	Ph	2-(benzo[d][1,3]dioxol-5-yl)ethanamine	3260
7E	49852487	104222760	S	Ph	2-(4-ethoxy-3-methoxyphenyl)ethanamine	21.6
8E	24512645	104222761	S	Ph	(3,4-dimethoxyphenyl)methanamine	101

*: no cytotoxicity at 33 μM (highest concentration tested); so CC₅₀ >33 μM by HCS cytotoxicity index

Probe Reports from the NIH Molecular Libraries Program [Internet].

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