| Predictors of tumor invasiveness or metastatic potential |
| TNM stage |
| Axillary lymph node status |
| Histologic subtype |
| Angiogenesis markers |
| Markers of cell proliferation |
| Oncogene and growth factor receptor expression |
| Protease expression |
| Predictors of organ-specific metastases |
| PTHrP expression |
| Vimentin expression |
| Bone marrow micrometastases |
| L-myc polymorphism |
| Predictors of tumor growth rate |
| Tumor differentiation |
| Estrogen and progesterone receptor expression |
| HER2/neu, EGFR, mutant p53, Cyclin-D |
| Proliferation markers (mitotic index, thymidine labeling index, S-phase fraction, Ki-67, PCNA) |
| Predictors of efficacy of systemic therapy |
| Hormone receptor expression (ER and PR) |
| Growth factor receptor (EGFR, HER2) expression |
| p53 mutation |
| BCL-2 expression |
| pgp expression |
From: Natural History and Prognostic Markers
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