Table 3.

Genetic Atypical Hemolytic-Uremic Syndrome: Mechanism of Disease Causation by Gene

Gene 1Mechanism of Disease Causation
C3 Gain of abnormal function
CD46 Loss of function
CFB Gain of abnormal function
CFH Loss of function
CFHR1 Unknown
CFHR3
CFHR4
CFHR5 Loss of function
CFI
DGKE
THBD
VTN Unknown

From: Genetic Atypical Hemolytic-Uremic Syndrome

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