Table 6, SAR Analysis of Probe 1: Modifications to Indoline Ring - Probe Reports from the NIH Molecular Libraries Program - NCBI Bookshelf

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Table 6SAR Analysis of Probe 1: Modifications to Indoline Ring

Entry No.	CID	*	Structure	Potency (µM)				Fold Selectivity
	SID			SR-BI-mediated lipid uptake		24-hour Cytotoxicity
	Broad ID			n	IC₅₀	n	IC₅₀
1	53377450	S		2	0.11	2	>35	>318
	125299408
	K55587176-019
2	53377427	S		2	0.28	2	15.7	>125
	125299415
	K31439710-001
3	53393833	S		4	0.10		NT	NT
	125333447
	K26007143-001
4	53377433	S		2	2.0	2	>35	>18
	125299412
	K14769165-001
5	53377426	S		6	0.066	2	>35	>530
	125299398
	K84589623-001
6	53393841	S		4	0.008	2	>35	>4375
	125333448
	K47808164-001
7	53393840	S		4	0.023		NT	NT
	125333444
	K01424506-001

: S=synthesized

From: A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 1

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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