Table 2, SAR Analysis of Probe 1 Western Amide: 5-Membered Heterocycles - Probe Reports from the NIH Molecular Libraries Program - NCBI Bookshelf

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Table 2SAR Analysis of Probe 1 Western Amide: 5-Membered Heterocycles

Entry No.	CID	*	Structure	Potency (µM)				Fold Selectivity
	SID			SR-BI-mediated lipid uptake		24-hour Cytotoxicity
	Broad ID			n	IC₅₀	n	IC₅₀
1	24761960	P		4	0.057	2	>35	>600
	49678600
	K10405667-001
2	53262914	S		4	9.8	2	>35	>3.5
	124404426
	K44559894-001
3	53347982	S		4	5.4	2	>35	>6.5
	125082007
	A49856563-001
4	53348009	S		4	2.1	2	>35	>17
	125082008
	K69660403-001
5	53262916	S		4	0.90	2	>35	>39
	124404425
	K55327617-001
6	53347968	S		2	14.1	2	>35	>2.5
	125082010
	K12056740-001
7	53347974	S		2	1.6	2	>35	>22
	125082020
	K64985467-001

: NT=not tested

From: A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 1

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Probe Reports from the NIH Molecular Libraries Program [Internet].

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