Table 5.

Recommended Surveillance for Men with BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer

System/ConcernEvaluationFrequency
Breast cancer Breast self-exam trainingAt the time of identification of a BRCA1 or BRCA2 pathogenic variant
Breast self-examMonthly beginning at age 35 yrs
Clinical breast examAnnually beginning at age 35 yrs
Prostate cancer Serum PSA; digital rectal examAnnually beginning at age 40 yrs
Melanoma Skin exam w/dermatologistIndividualized based on family history
Pancreatic
cancer 		In asymptomatic persons who meet criteria based on mutation status & family history, contrast-enhanced MRI/MRCP &/or EUS may be considered in a research setting to better delineate the risks & benefits of pancreatic cancer screening.

EUS = endoscopic ultrasound; MRCP = magnetic resonance cholangiopancreatography

From: BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer

Cover of GeneReviews®
GeneReviews® [Internet].
Adam MP, Feldman J, Mirzaa GM, et al., editors.
Seattle (WA): University of Washington, Seattle; 1993-2024.
Copyright © 1993-2024, University of Washington, Seattle. GeneReviews is a registered trademark of the University of Washington, Seattle. All rights reserved.

GeneReviews® chapters are owned by the University of Washington. Permission is hereby granted to reproduce, distribute, and translate copies of content materials for noncommercial research purposes only, provided that (i) credit for source (http://www.genereviews.org/) and copyright (© 1993-2024 University of Washington) are included with each copy; (ii) a link to the original material is provided whenever the material is published elsewhere on the Web; and (iii) reproducers, distributors, and/or translators comply with the GeneReviews® Copyright Notice and Usage Disclaimer. No further modifications are allowed. For clarity, excerpts of GeneReviews chapters for use in lab reports and clinic notes are a permitted use.

For more information, see the GeneReviews® Copyright Notice and Usage Disclaimer.

For questions regarding permissions or whether a specified use is allowed, contact: ude.wu@tssamda.

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.