Table 7. [Classic Ehlers-Danlos Syndrome: Recommended Surveillance]. - GeneReviews®

System/Concern	Evaluation	Frequency
Skin	Assessment for skin fragility	At each visit or as needed
Joints/Pain	Assessment for joint instability, occupational & physical therapy needs, mobility issues, pain
Neurologic	Eval for hypotonia & motor development	At each visit in infants & children
Hematologic	Assessment for easy bruising &/or prolonged bleeding	At each visit
Eval of clotting factors (platelet count, aPTT, PT, & thrombin time)	If severe easy bruising is present
Cardiovascular	Echocardiogram	In those w/normal initial echocardiogram: Children: frequency of follow up per pediatric cardiologist Adults: no follow-up echocardiogram necessary
In those w/abnormal echocardiogram (aortic dilatation, mitral valve prolapse): annually

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