Table 2, Frequency and age at onset of specific signs and symptoms of Fabry disease in male (n = 318) and female (n = 337) patients enrolled in FOS – the Fabry Outcome Survey - Fabry Disease

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	Frequency		Age at symptom onset (years)
	Proportion of population (%)	Number of patients	Mean ± SD	Number of patients
Males
Pain attacks	72	228	13 ± 12	165
Angiokeratomas	69	218	19 ± 14	130
Hypohidrosis	54	171	22 ± 16	105
Abdominal pain	40	128	23 ± 15	94
Diarrhoea	37	119	25 ± 17	79
Depression	24	76	32 ± 15	54
Proteinuria	48	154	33 ± 12	108
Hypertension	26	83	36 ± 13	53
Renal failure	20	64	36 ± 11	51
Left ventricular hypertrophy	43	136	39 ± 10	82
Stroke	9	28	39 ± 12	24
Angina	10	31	42 ± 5	22
Females
Pain attacks	52	174	19 ± 17	123
Angiokeratomas	36	122	30 ± 17	73
Hypohidrosis	25	84	25 ± 21	56
Abdominal pain	30	102	24 ± 20	73
Diarrhoea	20	66	22 ± 17	46
Depression	21	72	37 ± 16	54
Proteinuria	34	113	39 ± 17	81
Hypertension	18	60	46 ± 15	32
Renal failure	3	9	44 ± 16	8
Left ventricular hypertrophy	26	86	50 ± 11	50
Stroke	6	21	52 ± 14	18
Angina	11	37	49 ± 13	19

Fabry Disease: Perspectives from 5 Years of FOS.

Mehta A, Beck M, Sunder-Plassmann G, editors.

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