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SRCAP Mutations Drive Clonal Hematopoiesis Through Epigenetic and DNA Repair Dysregulation [RNA-seq]

(Submitter supplied) To investigate how Srcap mutations confer mutant hematopoietic stem and progenitor cells (HSPCs) with selective advantage after exposure to cellular stressors, transplantation and doxorubicin treatment We established Srcap heterozygous mutant murine model and utilized competitive bone marrow transplantation to assess the transcriptome of donor cells using RNA-seq
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30172
24 Samples
Download data: TXT
Series
Accession:
GSE229865
ID:
200229865

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