8TI2: Cryo-EM structure of a SUR1/Kir6.2-Q52R ATP-sensitive potassium channel in the presence of PIP2 in the open conformation

PDB ID: 8TI2Download
MMDB ID: 244978
PDB Deposition Date: 2023/7/18
Updated in MMDB: 2024/04
Experimental Method:
electron microscopy
Resolution: 3.28  Å
Source Organism:
Rattus norvegicus▼
Similar Structures:
Biological Unit for 8TI2: octameric; determined by author
Molecular Components in 8TI2
Label Count Molecule
Proteins (8 molecules)
4
Atp-sensitive Inward Rectifier Potassium Channel 11
Molecule annotation
4
Sur1
Molecule annotation
Chemicals and Non-standard biopolymers (28 molecules)
1
8
[(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate[(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate
2
4
POTASSIUM IONPOTASSIUM ION
3
4
DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINEDI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE
4
8
O-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serineO-[(R)-{[(2R)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-L-serine
5
4
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303