8THL: Cryo-EM structure of epinephrine-bound alpha-1A-adrenergic receptor in complex with heterotrimeric Gq-protein

PDB ID: 8THLDownload
MMDB ID: 234380
PDB Deposition Date: 2023/7/17
Updated in MMDB: 2023/08
Experimental Method:
electron microscopy
Resolution: 3.1  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8THL: pentameric; determined by author and by software
Molecular Components in 8THL
Label Count Molecule
Proteins (5 molecules)
1
Guanine Nucleotide-binding Protein G(i) Subunit Alpha-2,guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Short,guanine Nucleotide-binding Protein G(q) Subunit Alpha
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Single FAB Chain (Scfv16)
Molecule annotation
1
Endolysin,alpha-1a Adrenergic Receptor
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
L-EPINEPHRINEL-EPINEPHRINE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303