8THK: Cryo-EM structure of A61603-bound alpha-1A-adrenergic receptor in complex with heterotrimeric Gq-protein

PDB ID: 8THKDownload
MMDB ID: 234379
PDB Deposition Date: 2023/7/17
Updated in MMDB: 2023/08
Experimental Method:
electron microscopy
Resolution: 2.6  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 8THK: pentameric; determined by author and by software
Molecular Components in 8THK
Label Count Molecule
Proteins (5 molecules)
1
Guanine Nucleotide-binding Protein G(i) Subunit Alpha-2,guanine Nucleotide-binding Protein G(s) Subunit Alpha Isoforms Short,guanine Nucleotide-binding Protein G(q) Subunit Alpha
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Single FAB Chain (Scfv16)
Molecule annotation
1
Endolysin,alpha-1a Adrenergic Receptor
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-[(5S)-5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamideN-[(5S)-5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303