8IUM: Cryo-EM structure of the tafluprost acid-bound human PTGFR-Gq complex

PDB ID: 8IUMDownload
MMDB ID: 232891
PDB Deposition Date: 2023/3/24
Updated in MMDB: 2024/10
Experimental Method:
electron microscopy
Resolution: 3.14  Å
Source Organism:
Mus musculus▼
Similar Structures:
Biological Unit for 8IUM: hexameric; determined by author
Molecular Components in 8IUM
Label Count Molecule
Proteins (6 molecules)
1
G Subunit Alpha (Q)
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(t) Subunit Beta-1
Molecule annotation
1
Antibody Fragment Scfv16
Molecule annotation
1
Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-2
Molecule annotation
1
Nanobody Nb35
Molecule annotation
1
Prostaglandin F2-alpha Receptor
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E})-3,3-bis(fluoranyl)-4-phenoxy-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid(~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E})-3,3-bis(fluoranyl)-4-phenoxy-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303