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8CH6: Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex)

PDB ID:

8CH6 Download

MMDB ID:

230007

PDB Deposition Date:

2023/2/7

Updated in MMDB:

2024/07

Experimental Method:

electron microscopy

Resolution:

5.9 Å

Source Organism:

unidentified adenovirus▼

Taxonomy	Molecule
unidentified adenovirus	g
Homo sapiens	1, 2, 3, 4, 5, 8, 9, A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a , b, c, d, e, f, h, i, j, k, l, m, n, o, p, q, r, s, t, u, v, w, x, y, z

Similar Structures:

Biological Unit for 8CH6: 59-meric; determined by author

Molecular Components in 8CH6
Label	Count	Molecule
Proteins (55 molecules)
1 i	2	Small Nuclear Ribonucleoprotein E
2 h	2	Small Nuclear Ribonucleoprotein F
3 j	2	Small Nuclear Ribonucleoprotein SM D3
4 l	2	Small Nuclear Ribonucleoprotein SM D2
5 k	2	Small Nuclear Ribonucleoprotein SM D1
8 n	2	Small Nuclear Ribonucleoprotein-associated Proteins B and B'
9 m	2	Small Nuclear Ribonucleoprotein G
A	1	Splicing Factor 3B Subunit 3
B	1	Splicing Factor 3B Subunit 5
C	1	Splicing Factor 3B Subunit 1
D	1	PHD Finger-like Domain-containing Protein 5A
E	1	Splicing Factor 3B Subunit 2
F	1	Splicing Factor 3B Subunit 4
G	1	G-patch Domain and KOW Motifs-containing Protein
H	1	Splicing Factor 3A Subunit 1
I	1	Splicing Factor 3A Subunit 2
J	1	Splicing Factor 3A Subunit 3
K M R v	4	Pre-mrna-processing Factor 19
L	1	Bud13 Homolog
N	1	Putative Pre-mrna-splicing Factor Atp-dependent RNA Helicase Dhx16
O	1	Pleiotropic Regulator 1
P	1	Cell Division Cycle 5-like Protein
Q	1	Spliceosome-associated Protein Cwc15 Homolog
S	1	Pre-mrna-splicing Factor Spf27
T	1	Protein Bud31 Homolog
U	1	Pre-mrna-splicing Factor Rbm22
V	1	Peptidyl-prolyl Cis-trans Isomerase-like 4
W	1	Pre-mrna-splicing Factor Cwc22 Homolog
X	1	Crooked Neck-like Protein 1
Y	1	SNW Domain-containing Protein 1
Z	1	Ring Finger Protein 113a
a	1	Pre-mrna-processing-splicing Factor 8
b	1	116 KDA U5 Small Nuclear Ribonucleoprotein Component
c	1	U5 Small Nuclear Ribonucleoprotein 200 KDA Helicase
o	1	U5 Small Nuclear Ribonucleoprotein 40 KDA Protein
p	1	Peptidyl-prolyl Cis-trans Isomerase-like 1
q	1	Serine/arginine Repetitive Matrix Protein 2
r	1	U2 Small Nuclear Ribonucleoprotein A'
s	1	U2 Small Nuclear Ribonucleoprotein B''
t	1	Pre-mrna-splicing Factor Isy1 Homolog
u	1	Ring-type E3 Ubiquitin-protein Ligase Ppil2
w	1	Peptidyl-prolyl Cis-trans Isomerase E
x	1	Pre-mrna-processing Factor 17
y	1	Intron-binding Protein Aquarius
z	1	Pre-mrna-splicing Factor Syf1
Nucleotides(4 molecules)
d	1	Rnu6-1
e	1	Rnu5a-1
f	1	Rnu2-1
g	1	Minx-m3
Chemicals and Non-standard biopolymers (21 molecules)
1	12	ZINC ION
2	1	INOSITOL HEXAKISPHOSPHATE
3	1	GUANOSINE-5'-TRIPHOSPHATE
4	7	MAGNESIUM ION

* Click molecule labels to explore molecular sequence information.

Citing MMDB

Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303