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7W3A: Structure of USP14-bound human 26S proteasome in substrate-engaged state ED4_USP14

PDB ID:

7W3A Download

MMDB ID:

215193

PDB Deposition Date:

2021/11/25

Updated in MMDB:

2024/11

Experimental Method:

electron microscopy

Resolution:

3.5 Å

Source Organism:

Homo sapiens▼

Taxonomy	Molecule
Homo sapiens	A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, g, h, i, j, k, l, m, n, o, p, q, r, s, t , x, y, U, V, W, X, Y, Z, a, b, c, d, f, e
Saccharomyces cerevisiae	v

Similar Structures:

Biological Unit for 7W3A: 49-meric; determined by author

Molecular Components in 7W3A
Label	Count	Molecule
Proteins (49 molecules)
A	1	26S Protease Regulatory Subunit 7
B	1	26S Protease Regulatory Subunit 4
C	1	Isoform 2 of 26S Proteasome Regulatory Subunit 8
D	1	26S Protease Regulatory Subunit 6B
E	1	26S Proteasome Regulatory Subunit 10B
F	1	26S Protease Regulatory Subunit 6A
G g	2	Proteasome Subunit Alpha Type-6
H h	2	Proteasome Subunit Alpha Type-2
I i	2	Proteasome Subunit Alpha Type-4
J j	2	Proteasome Subunit Alpha Type-7
K k	2	Proteasome Subunit Alpha Type-5
L l	2	Isoform Long of Proteasome Subunit Alpha Type-1
M m	2	Proteasome Subunit Alpha Type-3
N n	2	Proteasome Subunit Beta Type-6
O o	2	Proteasome Subunit Beta Type-7
P p	2	Proteasome Subunit Beta Type-3
Q q	2	Proteasome Subunit Beta Type-2
R r	2	Proteasome Subunit Beta Type-5
S s	2	Proteasome Subunit Beta Type-1
T t	2	Proteasome Subunit Beta Type-4
v	1	Substrate
x	1	Ubiquitin Carboxyl-terminal Hydrolase 14
y	1	Ubiquitin
U	1	26S Proteasome Non-atpase Regulatory Subunit 1
V	1	26S Proteasome Non-atpase Regulatory Subunit 3
W	1	26S Proteasome Non-atpase Regulatory Subunit 12
X	1	26S Proteasome Non-atpase Regulatory Subunit 11
Y	1	26S Proteasome Non-atpase Regulatory Subunit 6
Z	1	26S Proteasome Non-atpase Regulatory Subunit 7
a	1	26S Proteasome Non-atpase Regulatory Subunit 13
b	1	26S Proteasome Non-atpase Regulatory Subunit 4
c	1	26S Proteasome Non-atpase Regulatory Subunit 14
d	1	26S Proteasome Non-atpase Regulatory Subunit 8
f	1	26S Proteasome Non-atpase Regulatory Subunit 2
e	1	26S Proteasome Complex Subunit Dss1
Chemicals and Non-standard biopolymers (7 molecules)
1	2	ADENOSINE-5'-DIPHOSPHATE (Link to PubChem not yet available)
2	4	ADENOSINE-5'-TRIPHOSPHATE (Link to PubChem not yet available)
3	1	ZINC ION (Link to PubChem not yet available)

* Click molecule labels to explore molecular sequence information.

Citing MMDB

Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303