6GVA: CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR4455

PDB ID: 6GVADownload
MMDB ID: 174868
PDB Deposition Date: 2018/6/20
Updated in MMDB: 2019/06
Experimental Method:
x-ray diffraction
Resolution: 2.15  Å
Source Organism:
Similar Structures:
Biological Unit for 6GVA: dimeric; determined by author and by software (PISA)
Molecular Components in 6GVA
Label Count Molecule
Proteins (2 molecules)
1
Cyclin-dependent Kinase 2
(Gene symbol: CDK2)
Molecule annotation
1
Cyclin-a2
(Gene symbol: CCNA2)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
5-(2-azanylethylsulfanyl)-3-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine5-(2-azanylethylsulfanyl)-3-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine
2
3
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
1
CHLORIDE IONCHLORIDE ION
4
1
BROMIDE IONBROMIDE ION
5
1
TETRAETHYLENE GLYCOLTETRAETHYLENE GLYCOL
6
1
MONOTHIOGLYCEROLMONOTHIOGLYCEROL
7
1
TRIETHYLENE GLYCOLTRIETHYLENE GLYCOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303