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6CKX:
Structure of CDK12/CycK in complex with a small molecule inhibitor N-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N-((1r,4r)-4-(quinazolin-2-ylamino)cyclohexyl)acetamide
PDB ID:
6CKX
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MMDB ID:
166138
PDB Deposition Date:
2018/3/1
Updated in MMDB:
2018/10
Experimental Method:
x-ray diffraction
Resolution:
2.8 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
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Biological Unit for 6CKX: dimeric; determined by author and by software (PISA)
Molecular Components in 6CKX
Label
Count
Molecule
Proteins (2 molecules)
A
1
Cyclin-dependent Kinase 12
(Gene symbol:
CDK12
)
B
1
Cyclin-k
(Gene symbol:
CCNK
)
Chemicals and Non-standard biopolymers (3 molecules)
1
2
MAGNESIUM ION
2
1
N-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-N-{trans-4-[(quinazolin-2-yl)amino]cyclohexyl}acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303