6CKX: Structure of CDK12/CycK in complex with a small molecule inhibitor N-(4-(1-methyl-1H-pyrazol-4-yl)phenyl)-N-((1r,4r)-4-(quinazolin-2-ylamino)cyclohexyl)acetamide

PDB ID: 6CKXDownload
MMDB ID: 166138
PDB Deposition Date: 2018/3/1
Updated in MMDB: 2018/10
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Similar Structures:
Biological Unit for 6CKX: dimeric; determined by author and by software (PISA)
Molecular Components in 6CKX
Label Count Molecule
Proteins (2 molecules)
1
Cyclin-dependent Kinase 12
(Gene symbol: CDK12)
Molecule annotation
1
Cyclin-k
(Gene symbol: CCNK)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
2
MAGNESIUM IONMAGNESIUM ION
2
1
N-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-N-{trans-4-[(quinazolin-2-yl)amino]cyclohexyl}acetamideN-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-N-{trans-4-[(quinazolin-2-yl)amino]cyclohexyl}acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303