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6AHD: The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution

PDB ID:	6AHD Download
MMDB ID:	171446
PDB Deposition Date:	2018/8/17
Updated in MMDB:	2021/07
Experimental Method:	electron microscopy
Resolution:	3.8 Å
Source Organism:	Homo sapiens
Similar Structures:

Biological Unit for 6AHD: 63-meric; determined by author

Molecular Components in 6AHD
Label	Count	Molecule
Proteins (58 molecules)
A	1	Pre-mrna-processing-splicing Factor 8
O	1	Thioredoxin-like Protein 4A
C	1	116 KDA U5 Small Nuclear Ribonucleoprotein Component
N	1	Pre-mrna-processing Factor 6
M	1	Nhp2-like Protein 1
L	1	U4/u6 Small Nuclear Ribonucleoprotein Prp31
9	1	U4/u6.u5 Tri-snrnp-associated Protein 1
J	1	U4/u6 Small Nuclear Ribonucleoprotein Prp3
a i U	3	SMB
b j V	3	Small Nuclear Ribonucleoprotein SM D1
c k P	3	Small Nuclear Ribonucleoprotein SM D2
d l Q	3	SME
e m R	3	SMF
f n S	3	Small Nuclear Ribonucleoprotein G
g h T	3	Small Nuclear Ribonucleoprotein SM D3
E	1	U5 Small Nuclear Ribonucleoprotein 40 KDA Protein
X	1	WW Domain-binding Protein 4
W	1	Peptidyl-prolyl Cis-trans Isomerase H
A0	1	Ubiquitin-like Protein 5
0	1	Microfibrillar-associated Protein 1
Z	1	Pre-mrna-splicing Factor 38A
8	1	Zinc Finger Matrin-type Protein 2
Y	1	Wd40 Repeat-containing Protein Smu1
o	1	U2 Small Nuclear Ribonucleoprotein A'
p	1	U2 Small Nuclear Ribonucleoprotein B''
u	1	Splicing Factor 3A Subunit 1
v	1	Splicing Factor 3A Subunit 2
w	1	Splicing Factor 3A Subunit 3
q	1	U6 Snrna-associated Sm-like Protein Lsm2
r	1	U6 Snrna-associated Sm-like Protein Lsm3
s	1	U6 Snrna-associated Sm-like Protein Lsm4
t	1	U6 Snrna-associated Sm-like Protein Lsm5
x	1	U6 Snrna-associated Sm-like Protein Lsm6
y	1	U6 Snrna-associated Sm-like Protein Lsm7
z	1	U6 Snrna-associated Sm-like Protein Lsm8
K	1	U4/u6 Small Nuclear Ribonucleoprotein Prp4
1	1	Splicing Factor 3B Subunit 1
3	1	Splicing Factor 3B Subunit 3
5	1	Sf3b14a, Splicing Factor 3B Subunit 6
6	1	PHD Finger-like Domain-containing Protein 5A
7	1	Sf3b5, Splicing Factor 3B Subunit 5
2	1	Sf3b145, Splicing Factor 3B Subunit 2
4	1	Sf3b49, Splicing Factor 3B Subunit 4
D	1	Brr2, U5 Small Nuclear Ribonucleoprotein 200 KDA Helicase
Nucleotides(5 molecules)
I	1	U4snrna
B	1	U5snrna
F	1	U6snrna
G	1	Pre-mrna
H	1	U2snrna
Chemicals and Non-standard biopolymers (3 molecules)
1	1	INOSITOL HEXAKISPHOSPHATE
2	1	GUANOSINE-5'-TRIPHOSPHATE
3	1	MAGNESIUM ION

* Click molecule labels to explore molecular sequence information.

Citing MMDB

Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303