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5TOB:
Selectivity switch between FAK and Pyk2: Macrocyclization of FAK inhibitors improves Pyk2 potency
PDB ID:
5TOB
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MMDB ID:
156640
PDB Deposition Date:
2016/10/17
Updated in MMDB:
2017/12
Experimental Method:
x-ray diffraction
Resolution:
2.117 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 5TOB: monomeric; determined by author
Molecular Components in 5TOB
Label
Count
Molecule
Protein (1 molecule)
A
1
Protein-tyrosine Kinase 2-beta
(Gene symbol:
PTK2B
)
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-methyl-N-{3-[({2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl}amino)methyl]pyridin-2-yl}methanesulfonamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303