5TFU: Structure of cytochrome P450 2D6 (CYP2D6) BACE1 inhibitor complex

PDB ID: 5TFUDownload
MMDB ID: 146350
PDB Deposition Date: 2016/9/26
Updated in MMDB: 2023/10
Experimental Method:
x-ray diffraction
Resolution: 2.75  Å
Source Organism:
Similar Structures:
Biological Unit for 5TFU: monomeric; determined by author and by software (PISA)
Molecular Components in 5TFU
Label Count Molecule
Protein (1 molecule)
1
Cytochrome P450 2D6
(Gene symbol: CYP2D6)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
PROTOPORPHYRIN IX CONTAINING FEPROTOPORPHYRIN IX CONTAINING FE
2
2
ZINC IONZINC ION
3
1
(4S,6R)-4-[2,4-difluoro-5-({[1-(trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-2-amine(4S,6R)-4-[2,4-difluoro-5-({[1-(trifluoromethyl)cyclopropyl]amino}methyl)phenyl]-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303