5SXE: Crystal Structure of PI3Kalpha in complex with fragments 19 and 28

PDB ID: 5SXEDownload
MMDB ID: 182249
PDB Deposition Date: 2016/8/9
Updated in MMDB: 2019/12
Experimental Method:
x-ray diffraction
Resolution: 3.51  Å
Source Organism:
Similar Structures:
Biological Unit for 5SXE: dimeric; determined by author and by software (PISA)
Molecular Components in 5SXE
Label Count Molecule
Proteins (2 molecules)
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Alpha Isoform
(Gene symbol: PIK3CA)
Molecule annotation
1
Phosphatidylinositol 3-kinase Regulatory Subunit Alpha
(Gene symbol: PIK3R1)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
3-aminobenzonitrile3-aminobenzonitrile
2
1
4-bromo-1H-imidazole4-bromo-1H-imidazole
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303