5LF3: Human 20S proteasome complex with Bortezomib at 2.1 Angstrom

PDB ID: 5LF3Download
MMDB ID: 142526
PDB Deposition Date: 2016/6/30
Updated in MMDB: 2022/11
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 5LF3: 28-meric; determined by software (PISA)
Molecular Components in 5LF3
Label Count Molecule
Proteins (28 molecules)
2
Proteasome Subunit Alpha Type-2
(Gene symbol: PSMA2)
Molecule annotation
2
Proteasome Subunit Alpha Type-4
(Gene symbol: PSMA4)
Molecule annotation
2
Proteasome Subunit Alpha Type-7
(Gene symbol: PSMA7)
Molecule annotation
2
Proteasome Subunit Alpha Type-5
(Gene symbol: PSMA5)
Molecule annotation
2
Proteasome Subunit Alpha Type-1
(Gene symbol: PSMA1)
Molecule annotation
2
Proteasome Subunit Alpha Type-3
(Gene symbol: PSMA3)
Molecule annotation
2
Proteasome Subunit Alpha Type-6
(Gene symbol: PSMA6)
Molecule annotation
2
Proteasome Subunit Beta Type-7
(Gene symbol: PSMB7)
Molecule annotation
2
Proteasome Subunit Beta Type-3
(Gene symbol: PSMB3)
Molecule annotation
2
Proteasome Subunit Beta Type-2
(Gene symbol: PSMB2)
Molecule annotation
2
Proteasome Subunit Beta Type-5
(Gene symbol: PSMB5)
Molecule annotation
2
Proteasome Subunit Beta Type-1
(Gene symbol: PSMB1)
Molecule annotation
2
Proteasome Subunit Beta Type-4
(Gene symbol: PSMB4)
Molecule annotation
2
Proteasome Subunit Beta Type-6
(Gene symbol: PSMB6)
Molecule annotation
Chemicals and Non-standard biopolymers (82 molecules)
1
51
CHLORIDE IONCHLORIDE ION
2
6
POTASSIUM IONPOTASSIUM ION
3
10
MAGNESIUM IONMAGNESIUM ION
4
9
PENTAETHYLENE GLYCOLPENTAETHYLENE GLYCOL
5
6
N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDEN-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303