5H25: EED in complex with PRC2 allosteric inhibitor compound 11

PDB ID: 5H25Download
MMDB ID: 146723
PDB Deposition Date: 2016/10/14
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2.88  Å
Source Organism:
Similar Structures:
Biological Unit for 5H25: dimeric; determined by author and by software (PISA)
Molecular Components in 5H25
Label Count Molecule
Proteins (2 molecules)
1
Polycomb Protein EED
(Gene symbol: EED)
Molecule annotation
1
Histone-lysine N-methyltransferase Ezh2
(Gene symbol: EZH2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline5-(2-fluorophenyl)-2,3-dihydroimidazo[2,1-a]isoquinoline
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303