5EMM: Crystal structure of PRMT5:MEP50 with Compound 15 and sinefungin

PDB ID: 5EMMDownload
MMDB ID: 136756
PDB Deposition Date: 2015/11/6
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.37  Å
Source Organism:
Similar Structures:
Biological Unit for 5EMM: octameric; determined by author and by software (PISA)
Molecular Components in 5EMM
Label Count Molecule
Proteins (8 molecules)
4
Protein Arginine N-methyltransferase 5
(Gene symbol: PRMT5)
Molecule annotation
4
Methylosome Protein 50
(Gene symbol: WDR77)
Molecule annotation
Chemicals and Non-standard biopolymers (16 molecules)
1
4
SINEFUNGINSINEFUNGIN
2
4
~{N}-[(2~{S})-3-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-propyl]-3-(oxan-4-ylamino)benzamide~{N}-[(2~{S})-3-(3,4-dihydro-1~{H}-isoquinolin-2-yl)-2-oxidanyl-propyl]-3-(oxan-4-ylamino)benzamide
3
8
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303