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4ZVV:
Lactate dehydrogenase A in complex with a trisubstituted piperidine-2,4-dione inhibitor GNE-140
PDB ID:
4ZVV
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MMDB ID:
139271
PDB Deposition Date:
2015/5/18
Updated in MMDB:
2023/10
Experimental Method:
x-ray diffraction
Resolution:
2.2 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4ZVV: tetrameric; determined by author and by software (PISA)
Molecular Components in 4ZVV
Label
Count
Molecule
Proteins (4 molecules)
A
B
C
D
4
L-lactate Dehydrogenase a Chain
(Gene symbol:
LDHA
)
Chemicals and Non-standard biopolymers (15 molecules)
1
4
NICOTINAMIDE-ADENINE-DINUCLEOTIDE
2
7
SULFATE ION
3
4
(2~{R})-5-(2-chlorophenyl)sulfanyl-2-(4-morpholin-4-ylphenyl)-4-oxidanyl-2-thiophen-3-yl-1,3-dihydropyridin-6-one
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303