4OQV: High resolution crystal structure of human dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine)

PDB ID: 4OQVDownload
MMDB ID: 120490
PDB Deposition Date: 2014/2/10
Updated in MMDB: 2014/07
Experimental Method:
x-ray diffraction
Resolution: 1.23  Å
Source Organism:
Similar Structures:
Biological Unit for 4OQV: monomeric; determined by author and by software (PISA)
Molecular Components in 4OQV
Label Count Molecule
Protein (1 molecule)
1
Dihydroorotate Dehydrogenase (Quinone), Mitochondrial
(Gene symbol: DHODH)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
1
FLAVIN MONONUCLEOTIDEFLAVIN MONONUCLEOTIDE
2
1
OROTIC ACIDOROTIC ACID
3
1
N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amineN-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
4
2
ACETIC ACIDACETIC ACID
5
1
GLYCEROLGLYCEROL
6
2
SODIUM IONSODIUM ION
7
1
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303