4IA0: Crystal Structure Of The Pde5a1 Catalytic Domain In Complex With Novel Inhibitors

PDB ID: 4IA0Download
MMDB ID: 116362
PDB Deposition Date: 2012/12/5
Updated in MMDB: 2014/01
Experimental Method:
x-ray diffraction
Resolution: 2.17  Å
Source Organism:
Similar Structures:
Biological Unit for 4IA0: monomeric; determined by author
Molecular Components in 4IA0
Label Count Molecule
Protein (1 molecule)
1
Cgmp-specific 3',5'-cyclic Phosphodiesterase
(Gene symbol: PDE5A)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
5-Bromo-2-{2-Ethoxy-5-[(4-Methylpiperazin-1-Yl)sulfonyl]phenyl}-6-Octylpyrimidin-4(3h)-One5-Bromo-2-{2-Ethoxy-5-[(4-Methylpiperazin-1-Yl)sulfonyl]phenyl}-6-Octylpyrimidin-4(3h)-One
2
1
Zinc IonZinc Ion
3
1
Magnesium IonMagnesium Ion
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303