3V5Q: Discovery of a selective TRK Inhibitor with efficacy in rodent cancer tumor models

PDB ID: 3V5QDownload
MMDB ID: 97120
PDB Deposition Date: 2011/12/16
Updated in MMDB: 2024/03
Experimental Method:
x-ray diffraction
Resolution: 2.2001  Å
Source Organism:
Similar Structures:
Biological Unit for 3V5Q: monomeric; determined by author and by software (PISA)
Molecular Components in 3V5Q
Label Count Molecule
Protein (1 molecule)
1
Nt-3 Growth Factor Receptor
(Gene symbol: NTRK3)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
CHLORIDE IONCHLORIDE ION
2
1
1-(3-{[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-6-yl]amino}phenyl)-3-[3-(trifluoromethyl)phenyl]urea1-(3-{[(3Z)-2-oxo-3-(1H-pyrrol-2-ylmethylidene)-2,3-dihydro-1H-indol-6-yl]amino}phenyl)-3-[3-(trifluoromethyl)phenyl]urea
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303