3SFF: Crystal Structure of Human HDAC8 Inhibitor Complex, an Amino Acid Derived Inhibitor

PDB ID: 3SFFDownload
MMDB ID: 92211
PDB Deposition Date: 2011/6/13
Updated in MMDB: 2011/08
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 3SFF: monomeric; determined by author and by software (PISA)
Molecular Components in 3SFF
Label Count Molecule
Protein (1 molecule)
1
Histone Deacetylase 8
(Gene symbol: HDAC8)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
(2R)-2-amino-3-(3-chlorophenyl)-1-[4-(2,5-difluorobenzoyl)piperazin-1-yl]propan-1-one(2R)-2-amino-3-(3-chlorophenyl)-1-[4-(2,5-difluorobenzoyl)piperazin-1-yl]propan-1-one
2
2
POTASSIUM IONPOTASSIUM ION
3
1
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303