3S3M: Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and Dolutegravir (S/GSK1349572)

PDB ID: 3S3MDownload
MMDB ID: 91579
PDB Deposition Date: 2011/5/18
Updated in MMDB: 2011/10
Experimental Method:
x-ray diffraction
Resolution: 2.49  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 3S3M: octameric; determined by author and by software (PISA)
Molecular Components in 3S3M
Label Count Molecule
Proteins (4 molecules)
4
PFV Integrase
Molecule annotation
Nucleotides(4 molecules)
2
5'-d(*ap*tp*tp*gp*tp*cp*ap*tp*gp*gp*ap*ap*tp*tp*tp*cp*gp*cp*a)-3'
Molecule annotation
2
5'-d(*tp*gp*cp*gp*ap*ap*ap*tp*tp*cp*cp*ap*tp*gp*ap*cp*a)-3'
Molecule annotation
Chemicals and Non-standard biopolymers (24 molecules)
1
2
ZINC IONZINC ION
2
4
SULFATE IONSULFATE ION
3
8
GLYCEROLGLYCEROL
4
2
AMMONIUM IONAMMONIUM ION
5
4
MAGNESIUM IONMAGNESIUM ION
6
2
(4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide(4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
7
2
HEXANE-1,6-DIOLHEXANE-1,6-DIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303