3OW3: Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

PDB ID: 3OW3Download
MMDB ID: 86143
PDB Deposition Date: 2010/9/17
Updated in MMDB: 2010/11
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 3OW3: dimeric; determined by author and by software (PISA)
Molecular Components in 3OW3
Label Count Molecule
Proteins (2 molecules)
1
Camp-dependent Protein Kinase Catalytic Subunit Alpha
(Gene symbol: Prkaca)
Molecule annotation
1
Camp-dependent Protein Kinase Inhibitor Alpha
(Gene symbol: Pkia)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
(2R)-3-(1H-indol-3-yl)-1-{4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}-1-oxopropan-2-amine(2R)-3-(1H-indol-3-yl)-1-{4-[(5S)-5-methyl-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}-1-oxopropan-2-amine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303