3OOM: Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00507

PDB ID: 3OOMDownload
MMDB ID: 85518
PDB Deposition Date: 2010/8/31
Updated in MMDB: 2023/11
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 3OOM: dimeric; determined by author and by software (PISA)
Molecular Components in 3OOM
Label Count Molecule
Proteins (2 molecules)
2
Activin Receptor Type-1
(Gene symbol: ACVR1)
Molecule annotation
Chemicals and Non-standard biopolymers (33 molecules)
1
4
PHOSPHATE IONPHOSPHATE ION
2
2
1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone1-{3-[6-(tetrahydro-2H-pyran-4-ylamino)imidazo[1,2-b]pyridazin-3-yl]phenyl}ethanone
3
27
1,2-ETHANEDIOL1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303