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2ZIR:
Crystal Structure of rat protein farnesyltransferase complexed with a benzofuran inhibitor and FPP
PDB ID:
2ZIR
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MMDB ID:
69786
PDB Deposition Date:
2008/2/22
Updated in MMDB:
2023/11
Experimental Method:
x-ray diffraction
Resolution:
2.4 Å
Source Organism:
Rattus norvegicus
Similar Structures:
VAST+
Download sequence data
Biological Unit for 2ZIR: dimeric; determined by author and by software (PISA)
Molecular Components in 2ZIR
Label
Count
Molecule
Proteins (2 molecules)
A
1
Protein Farnesyltransferase Subunit Alpha
(Gene symbol:
Fnta
)
B
1
Protein Farnesyltransferase Subunit Beta
(Gene symbol:
Fntb
)
Chemicals and Non-standard biopolymers (10 molecules)
1
5
GLYCEROL
2
1
ZINC ION
3
1
FARNESYL DIPHOSPHATE
4
1
2-[(S)-(4-chlorophenyl)(hydroxy)(1-methyl-1H-imidazol-5-yl)methyl]-N-morpholin-4-yl-7-phenyl-1-benzofuran-5-carboxamide
5
2
Molecule information is not available.
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303