1S63: Human protein farnesyltransferase complexed with L-778,123 and FPP

PDB ID: 1S63Download
MMDB ID: 28560
PDB Deposition Date: 2004/1/22
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
Similar Structures:
Biological Unit for 1S63: dimeric; determined by author and by software (PISA)
Molecular Components in 1S63
Label Count Molecule
Proteins (2 molecules)
1
Protein Farnesyltransferase/geranylgeranyltransferase Type I Alpha Subunit
(Gene symbol: FNTA)
Molecule annotation
1
Protein Farnesyltransferase Beta Subunit
(Gene symbol: FNTB)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
alpha-D-glucopyranosealpha-D-glucopyranose
2
1
beta-D-fructofuranosebeta-D-fructofuranose
3
1
ZINC IONZINC ION
4
1
FARNESYL DIPHOSPHATEFARNESYL DIPHOSPHATE
5
1
4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE4-[(5-{[4-(3-CHLOROPHENYL)-3-OXOPIPERAZIN-1-YL]METHYL}-1H-IMIDAZOL-1-YL)METHYL]BENZONITRILE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303