1PJ3: Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a pentary complex with natural substrate pyruvate, cofactor NAD+, Mn++, and allosteric activator fumarate

PDB ID: 1PJ3Download
MMDB ID: 25337
PDB Deposition Date: 2003/5/30
Updated in MMDB: 2003/12
Experimental Method:
x-ray diffraction
Resolution: 2.1  Å
Source Organism:
Similar Structures:
Biological Unit for 1PJ3: tetrameric; determined by author and by software (PISA)
Molecular Components in 1PJ3
Label Count Molecule
Proteins (4 molecules)
4
Nad-dependent Malic Enzyme, Mitochondrial
(Gene symbol: ME2)
Molecule annotation
Chemicals and Non-standard biopolymers (20 molecules)
1
4
MANGANESE (II) IONMANGANESE (II) ION
2
4
PYRUVIC ACIDPYRUVIC ACID
3
8
NICOTINAMIDE-ADENINE-DINUCLEOTIDENICOTINAMIDE-ADENINE-DINUCLEOTIDE
4
4
FUMARIC ACIDFUMARIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303