Conserved Protein Domain Family
SNX27_RA
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cd01777: SNX27_RA (this model, PSSM-Id:176372 is obsolete and has been replaced by 340475)
Ubiquitin domain of SNX27 (sorting nexin protein 27)
SNX27_RA SNX27 (sorting nexin protein 27) belongs to a large family of endosome-localized proteins related to sorting nexin1 which is implicated in regulating membrane traffic. The domain architecture of SNX27 includes an amino-terminal PDZ domain, a PX (PhoX homologous) domain, and a carboxy-terminal RA (RAS-associated) domain.
Links
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Statistics
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PSSM-Id: 176372
Aligned: 6 rows
Threshold Bit Score: 160.465
Created: 31-Jul-2004
Updated: 17-Jan-2013
Structure
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Aligned Rows:
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putative Ras
Feature 1:putative Ras interaction site [polypeptide binding site]
Evidence:
  • Comment:interacts with the switch I and switch II regions of Ras
  • Citation:PMID 9628477
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1       # #       ## ##   ##       #  ##                                              
AAK97797  181 DVELRVALPDGTTVTVRVKKNSTTDQVYQAIAAKVgmdstTVNYFALFEVISHSFVRKLAPNEFPHKLYIQNYtsavpGT 260 human
NP_690060 272 DVELRVALPDGATVTVRVKKNSTTDQVYQAIAAKVgmdstTVNYFALFEVINHSFVRKLAPNEFPHKLYVQNYtsavpGT 351 Norway rat
NP_956834 279 DVELRIAMPDKTTVTVRVRKNCTTDQVYQAVVTKIgmdsiTASYFALFEVINHTFARKLAPNEFPHKLYVQNYtsavpGT 358 zebrafish
XP_322054 306 PVDIKIMLPDHAVVTVSVRKSANAQLVWEQLVQRAnltsyTQQYFYLFEIVEYNFERKLQPHEIPHQLYVQNYst-asST 384 Anopheles gambiae ...
AAH68958  155 DVELRIALPDKSTVTVRVKKNSTTDQVYQALGAKIgmdaiTANYFALFEVINHSFVRKLAPNEFPHKLYVQNYtsavpGT 234 African clawed frog
CAG11857  200 DVELRIALPDKTALTVRVRKNATTDQVYQAVVTKLgmdsvTSSYFALFEVINHTFVRKLAPNEFPHKLYVQNYtsaipGT 279 Tetraodon nigrovir...

Feature 1            
AAK97797  261 CLTIRKW 267 human
NP_690060 352 CLTIRKW 358 Norway rat
NP_956834 359 CLTLRKW 365 zebrafish
XP_322054 385 CLCAVDE 391 Anopheles gambiae str. PEST
AAH68958  235 CLTVRKW 241 African clawed frog
CAG11857  280 CLTMRKW 286 Tetraodon nigroviridis

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