Conserved Protein Domain Family
FERM_F1_SNX27
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cd01777: FERM_F1_SNX27 
FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in sorting nexin protein 27 (SNX27)
SNX27 is a member of the family of cytoplasmic sorting nexin adaptor proteins that regulate endosomal trafficking of cell surface proteins. In addition to a PX (Phox homology) domain that regulates its endosomal localization, SNX27 has a unique PDZ (Psd-95/Dlg/ZO1) domain and an atypical FERM (4.1, ezrin, radixin, moesin) domain that both function to bind short peptide sequence motifs in the cytoplasmic domains of the cargo receptors. The FERM domain is made up of three sub-domains, F1, F2, and F3. This family corresponds to the F1 sub-domain, which is also called the N-terminal ubiquitin-like structural domain of the FERM domain (FERM_N).
Links
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Statistics
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PSSM-Id: 340475
Aligned: 16 rows
Threshold Bit Score: 142.439
Created: 31-Jul-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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key conserved
Feature 1: key conserved lysines, 2 residue positions
Conserved feature residue pattern:[KR] [KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:2(K33/r, K48/R, Ub numbering) of the 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering) are conserved in this family; may have roles other than chain linkage
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                          #                      #                      
Q96L92       273 SDVELRVALPDGTTVTVRVKKnSTTDQVYQAIAAKVGMdstTVNYFALFEVISHSFVRKLAPnEFPHKLYIQNYTSAv-p 351 human
AAH68958     154 SDVELRIALPDKSTVTVRVKKnSTTDQVYQALGAKIGMdaiTANYFALFEVINHSFVRKLAPnEFPHKLYVQNYTSAv-p 232 African clawed ...
XP_002732720 263 TEVELRVLLPDRNTLTVTVRRnSPTDEVYEAVVDKLGMdeeTANVFALYEIMDYTFERKLSPnEFPHNLYIQNYSTAt-- 340 Saccoglossus ko...
XP_002609888 256 AEVDLRVLLPDRSTLTVTIRRnNNTDQVYDAVVDKLGLdeeLLPYFGLFEIMDTNFERKLVPtEFPHNLYIQNYTTAa-- 333 Florida lancelet
CAG32282     261 SDVELRVALPDITTVTVRVKKnSTTDQVYQAVAAKVGMdsvTANYFALFEVINHSFVRKLAPnEFPHKLYVQNYTSAv-p 339 chicken
XP_011674492 259 VQVEMRINLPDRTSVTVSVRRnNTADDVYNSLVHKIALdkgMVNYFYLFETTESGFDRKLLRtEFPHNLYIQNYSSAkpn 338 purple sea urchin
NP_001038565 276 TDVELRIALPDKTTASVRVQKnSTTDQVYQALVVKVGMdsmMASYFALFEVINHSFVRKLAPnEFPHKLYVQNYTSAv-p 354 zebrafish
XP_013391118 257 DEVELKVLLPDRKVLTVAIKRsSVTDEVYEAVVRKLGMtdeTAKYFYLFEILDDTFDRKLLYsDFPHSLYIQNYSTAe-- 334 Lingula anatina
KXJ07742     252 MEVELRILMPDNTTVSVGIEKkNKTRQVYKALLKKIGLqeeNAINFALFEIMESGFERKLRMnEFPHNLYIRRYTESs-- 329 Exaiptasia pallida
EEC14045     267 SLVDLKVLLPDRTTVVVKLERcLSISQVYQAVVEKAAIpseVARYFALFEIVEYGFERRLGPsEFPHNLYIQNYSTAt-- 344 black-legged tick

Feature 1                      
Q96L92       352 GTCLTIRKWLFTTE 365 human
AAH68958     233 GTCLTVRKWLFTTS 246 African clawed frog
XP_002732720 341 NTCLALRKWIFAVH 354 Saccoglossus kowalevskii
XP_002609888 334 STCIALRKWLFDLQ 347 Florida lancelet
CAG32282     340 GTCLTIRKWLFTTE 353 chicken
XP_011674492 339 ESCIALRKWVFAPT 352 purple sea urchin
NP_001038565 355 GTCLTMRKWLFSTQ 368 zebrafish
XP_013391118 335 ATCIALKKWVFTLS 348 Lingula anatina
KXJ07742     330 NTCLTIRKWIFTLS 343 Exaiptasia pallida
EEC14045     345 STCLLVRKWLFTRE 358 black-legged tick

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