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MET MET proto-oncogene, receptor tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 4233, updated on 14-Nov-2024

Summary

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Official Symbol
METprovided by HGNC
Official Full Name
MET proto-oncogene, receptor tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:7029
See related
Ensembl:ENSG00000105976 MIM:164860; AllianceGenome:HGNC:7029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DA11; HGFR; AUTS9; RCCP2; c-Met; DFNB97
Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Expression
Broad expression in placenta (RPKM 12.8), liver (RPKM 11.3) and 20 other tissues See more
Orthologs
mouse all
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Genomic context

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See MET in Genome Data Viewer
Location:
7q31.2
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (116672196..116798377)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (117987305..118113574)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116312250..116438431)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26534 Neighboring gene Sharpr-MPRA regulatory region 9016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18558 Neighboring gene Sharpr-MPRA regulatory region 15503 Neighboring gene caveolin 2 Neighboring gene caveolin 1 Neighboring gene Sharpr-MPRA regulatory region 6449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18559 Neighboring gene greater CFTR locus negative regulatory element NR2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26536 Neighboring gene cytosolic oncogenic antisense to MET transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26537 Neighboring gene MPRA-validated peak6696 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:116273493-116274692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18562 Neighboring gene greater CFTR locus negative regulatory element CR3 Neighboring gene greater CFTR locus negative regulatory element CR5 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:116363882-116365081 Neighboring gene uncharacterized LOC124901824 Neighboring gene greater CFTR locus negative regulatory element CR6 Neighboring gene greater CFTR locus negative regulatory element CR8 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:116412324-116413523 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:116416081-116417280 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:116420832-116421760 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:116421761-116422688 Neighboring gene uncharacterized LOC124901731 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:116496945-116497602 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:116502260-116503022 Neighboring gene RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing pseudogene Neighboring gene capping actin protein of muscle Z-line subunit alpha 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization.
    Title: The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization.
  2. Single-molecule imaging and molecular dynamics simulations reveal early activation of the MET receptor in cells.
    Title: Single-molecule imaging and molecular dynamics simulations reveal early activation of the MET receptor in cells.
  3. MET exon 14 skipping mutations in non-small-cell lung cancer: real-world data from the Italian biomarker ATLAS database.
    Title: MET exon 14 skipping mutations in non-small-cell lung cancer: real-world data from the Italian biomarker ATLAS database.
  4. Differential Immune Checkpoint Protein Expression in HNSCC: The Role of HGF/MET Signaling.
    Title: Differential Immune Checkpoint Protein Expression in HNSCC: The Role of HGF/MET Signaling.
  5. PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility.
    Title: PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility.
  6. Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis.
    Title: Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis.
  7. Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells.
    Title: Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells.
  8. MET alterations in advanced non-small cell lung cancer.
    Title: MET alterations in advanced non-small cell lung cancer.
  9. MET overexpression correlated with prognosis of EGFR-mutant treatment-naive advanced lung adenocarcinoma: a real-world retrospective study.
    Title: MET overexpression correlated with prognosis of EGFR-mutant treatment‑naïve advanced lung adenocarcinoma: a real‑world retrospective study.
  10. Clinical, pathologic, and genomic characteristics of two pediatric glioneuronal tumors with a CLIP2::MET fusion.
    Title: Clinical, pathologic, and genomic characteristics of two pediatric glioneuronal tumors with a CLIP2::MET fusion.
Submit: New GeneRIF Correction See all GeneRIFs (1253)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Arthrogryposis, distal, IIa 11
MedGen: C5774205 OMIM: 620019 GeneReviews: Not available
not available
Autosomal recessive nonsyndromic hearing loss 97
MedGen: C4084709 OMIM: 616705 GeneReviews: Not available
not available
Hepatocellular carcinoma
MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
not available
Osteofibrous dysplasia
MedGen: C4085248 OMIM: 607278 GeneReviews: Not available
not available
Papillary renal cell carcinoma type 1
MedGen: C1336839 OMIM: 605074 GeneReviews: Not available
not available

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-09-06)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-09-06)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Genetic determinants of P wave duration and PR segment.
EBI GWAS Catalog
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GPI-linked ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables boss receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables brain-derived neurotrophic factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables epidermal growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables fibroblast growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables hepatocyte growth factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H2AXY142 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3Y41 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables insulin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables insulin-like growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables macrophage colony-stimulating factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular function activator activity EXP
Inferred from Experiment
more info
 PubMed 
enables placental growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables platelet-derived growth factor alpha-receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables platelet-derived growth factor beta-receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
  
enables protein tyrosine kinase collagen receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables semaphorin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables stem cell factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane-ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables vascular endothelial growth factor receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Kit signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in endothelial cell morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ephrin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in hepatocyte growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in liver development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in macrophage colony-stimulating factor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of autophagy NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of hydrogen peroxide-mediated programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of thrombin-activated receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pancreas development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive chemotaxis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of endothelial cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basal plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
hepatocyte growth factor receptor
Names
HGF receptor
HGF/SF receptor
SF receptor
proto-oncogene c-Met
scatter factor receptor
tyrosine-protein kinase Met
NP_000236.2
NP_001120972.1
NP_001311330.1
NP_001311331.1
XP_011514525.1
XP_047276356.1
XP_054214230.1
XP_054214231.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008996.1 RefSeqGene

    Range
    5001..130982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_662

mRNA and Protein(s)

  1. NM_000245.4 → NP_000236.2  hepatocyte growth factor receptor isoform b preproprotein

    See identical proteins and their annotated locations for NP_000236.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AA278232, AC002080, BX648782, DB223186, X54559
    Consensus CDS
    CCDS43636.1
    UniProtKB/Swiss-Prot
    A1L467, B5A932, E7EQ94, O60366, P08581, Q12875, Q9UDX7, Q9UPL8
    Related
    ENSP00000380860.3, ENST00000397752.8
    Conserved Domains (7) summary
    cd11278
    Location:25 → 516
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00423
    Location:519 → 561
    PSI; domain found in Plexins, Semaphorins and Integrins
    smart00429
    Location:838 → 934
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:657 → 740
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:563 → 656
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:742 → 837
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:1082 → 1343
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

  2. NM_001127500.3 → NP_001120972.1  hepatocyte growth factor receptor isoform a preproprotein

    See identical proteins and their annotated locations for NP_001120972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC002080, AC002543, BC130420, BX648782, DB223186, J02958
    Consensus CDS
    CCDS47689.1
    Related
    ENSP00000317272.6, ENST00000318493.11
    Conserved Domains (8) summary
    cd11278
    Location:25 → 516
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00423
    Location:519 → 561
    PSI; domain found in Plexins, Semaphorins and Integrins
    smart00429
    Location:856 → 952
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:657 → 740
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:563 → 656
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:1100 → 1361
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam07714
    Location:1096 → 1355
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:742 → 855
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  3. NM_001324401.3 → NP_001311330.1  hepatocyte growth factor receptor isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform c, which lacks a portion of the beta subunit.
    Source sequence(s)
    AC002080, DB223186, EU176015
    UniProtKB/TrEMBL
    B5A929, E6Y365, H7C174
    Related
    ENSP00000398776.2, ENST00000422097.2
    Conserved Domains (6) summary
    cd11278
    Location:25 → 516
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00423
    Location:519 → 561
    PSI; domain found in Plexins, Semaphorins and Integrins
    smart00429
    Location:838 → 918
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:657 → 740
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:563 → 656
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cl15674
    Location:742 → 837
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  4. NM_001324402.2 → NP_001311331.1  hepatocyte growth factor receptor isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes isoform d, which lacks a predicted signal peptide compared to isoforms a-c.
    Source sequence(s)
    AC002080, AC002543, AC004416, AI630755
    UniProtKB/TrEMBL
    B4DLF5
    Conserved Domains (8) summary
    smart00423
    Location:89 → 131
    PSI; domain found in Plexins, Semaphorins and Integrins
    smart00429
    Location:408 → 504
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:227 → 310
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:133 → 226
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:652 → 913
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam07714
    Location:648 → 907
    Pkinase_Tyr; Protein tyrosine kinase
    cl15674
    Location:312 → 407
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:1 → 86
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    116672196..116798377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516223.2 → XP_011514525.1  hepatocyte growth factor receptor isoform X1

    Conserved Domains (8) summary
    cd11278
    Location:44 → 535
    Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
    smart00423
    Location:538 → 580
    PSI; domain found in Plexins, Semaphorins and Integrins
    smart00429
    Location:857 → 953
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:676 → 759
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:582 → 675
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01181
    Location:761 → 856
    IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:1101 → 1362
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam07714
    Location:1097 → 1356
    Pkinase_Tyr; Protein tyrosine kinase

  2. XM_047420400.1 → XP_047276356.1  hepatocyte growth factor receptor isoform X2

    Related
    ENSP00000410980.2, ENST00000436117.3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    117987305..118113574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358255.1 → XP_054214230.1  hepatocyte growth factor receptor isoform X1

  2. XM_054358256.1 → XP_054214231.1  hepatocyte growth factor receptor isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08581.4 GenPept UniProtKB/Swiss-Prot:P08581

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous