Arnt aryl hydrocarbon receptor nuclear translocator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arntprovided by MGI
Official Full Name: aryl hydrocarbon receptor nuclear translocatorprovided by MGI
Primary source: MGI:MGI:88071
See related: Ensembl:ENSMUSG00000015522 AllianceGenome:MGI:88071
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Drnt; Hif1b; ESTM42; bHLHe2; mKIAA4051; D3Ertd557e
Summary: Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Contributes to nuclear receptor activity. Involved in positive regulation of protein sumoylation. Acts upstream of or within several processes, including embryonic placenta development; positive regulation of transcription by RNA polymerase II; and response to hypoxia. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human ARNT (aryl hydrocarbon receptor nuclear translocator). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 15.4), ovary adult (RPKM 15.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.74 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (95341674..95404551)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (95434367..95497240)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evidence for crosstalk between the aryl hydrocarbon receptor and the translocator protein in mouse lung epithelial cells.
Title: Evidence for crosstalk between the aryl hydrocarbon receptor and the translocator protein in mouse lung epithelial cells.
Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice.
Title: Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice.
Aryl hydrocarbon receptor nuclear translocator limits the recruitment and function of regulatory neutrophils against colorectal cancer by regulating the gut microbiota.
Title: Aryl hydrocarbon receptor nuclear translocator limits the recruitment and function of regulatory neutrophils against colorectal cancer by regulating the gut microbiota.
Effects of Myeloid Hif-1beta Deletion on the Intestinal Microbiota in Mice under Environmental Hypoxia.
Title: Effects of Myeloid Hif-1β Deletion on the Intestinal Microbiota in Mice under Environmental Hypoxia.
Loss of ARNT in skeletal muscle limits muscle regeneration in aging.
Title: Loss of ARNT in skeletal muscle limits muscle regeneration in aging.
Animals with myeloid ARNT deletion developed steatohepatitis on a high fat diet.
Title: Myeloid cell deletion of Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) induces non-alcoholic steatohepatitis.
These data show that L. major infection induces macrophage VEGF-A production in an ARNT/HIF-dependent manner and suggest that ARNT/HIF signaling may limit inflammation by promoting VEGF-A production and, thus, lymphangiogenesis during infection.
Title: Leishmania Infection Induces Macrophage Vascular Endothelial Growth Factor A Production in an ARNT/HIF-Dependent Manner.
Mice lacking ARNT/HIF1beta in pancreatic beta-cells have altered lipid signaling in vivo and are resistant to a high fat diet's ability to induce diabetes.
Title: The Loss of ARNT/HIF1β in Male Pancreatic β-Cells Is Protective Against High-Fat Diet-Induced Diabetes.
traditional vascular remodeling responses are insufficient to provide robust peripheral tissue reperfusion in Arnt(SMKO) mice. In all, this study highlights HIF responses to hypoxia in arteriole VSMCs critical for the phenotypic and functional stability of vessels that aid in the recovery of blood flow in ischemic peripheral tissues.
Title: Aryl Hydrocarbon Receptor Nuclear Translocator in Vascular Smooth Muscle Cells Is Required for Optimal Peripheral Perfusion Recovery.
we report a renoprotective mechanism that is controlled by the transcription factor ARNT, which effectively inhibits progression of chronic kidney injury by inducing ALK3 transcription
Title: Pharmacological induction of hypoxia-inducible transcription factor ARNT attenuates chronic kidney failure.

Submit: New GeneRIF Correction See all GeneRIFs (55)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Umi11 (e-PCR), detects polymorphism
- UniSTS:281089

PMC228437P1 (e-PCR)
- UniSTS:272158

Arnt (e-PCR), detects polymorphism
- UniSTS:141123

Arnt (e-PCR), detects polymorphism
- UniSTS:461902

D2Wox41 (e-PCR)
- UniSTS:518771

W08714 (e-PCR), detects polymorphism
- UniSTS:143028

AU022700 (e-PCR)
- UniSTS:167367

Arnt (e-PCR), detects polymorphism
- UniSTS:528857

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI Inferred from Genetic Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables aryl hydrocarbon receptor binding	IEA Inferred from Electronic Annotation more info
enables aryl hydrocarbon receptor binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info	PubMed
contributes_to nuclear receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to nuclear receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to nuclear receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic placenta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hormone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hormone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein sumoylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to toxic substance	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
part_of aryl hydrocarbon receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
part_of nuclear aryl hydrocarbon receptor complex	ISO Inferred from Sequence Orthology more info
part_of nuclear aryl hydrocarbon receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: aryl hydrocarbon receptor nuclear translocator

Names: HIF-1-beta; HIF1-beta; dioxin receptor, nuclear translocator; hypoxia-inducible factor 1-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037737.2 → NP_001032826.1 aryl hydrocarbon receptor nuclear translocator isoform a

See identical proteins and their annotated locations for NP_001032826.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AC092203, AK145415, AK153355, CJ183661

Consensus CDS

CCDS17614.1

UniProtKB/Swiss-Prot

P53762, Q60661, Q921F3

UniProtKB/TrEMBL

Q3U7X2

Related

ENSMUSP00000099810.5, ENSMUST00000102749.11

Conserved Domains (5) summary

smart00091
Location:166 → 230

PAS; PAS domain

cd00130
Location:362 → 458

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:91 → 143

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:163 → 269

PAS; PAS fold

pfam14598
Location:362 → 462

PAS_11; PAS domain
NM_001409517.1 → NP_001396446.1 aryl hydrocarbon receptor nuclear translocator isoform c

Status: VALIDATED

Source sequence(s)

AC092202, AC092203
NM_001409518.1 → NP_001396447.1 aryl hydrocarbon receptor nuclear translocator isoform d

Status: VALIDATED

Source sequence(s)

AC092202, AC092203
NM_001409519.1 → NP_001396448.1 aryl hydrocarbon receptor nuclear translocator isoform e

Status: VALIDATED

Source sequence(s)

AC092202, AC092203
NM_001409520.1 → NP_001396449.1 aryl hydrocarbon receptor nuclear translocator isoform f

Status: VALIDATED

Source sequence(s)

AC092202, AC092203

UniProtKB/TrEMBL

Q8CEC2

Related

ENSMUSP00000102779.2, ENSMUST00000107161.8
NM_001409522.1 → NP_001396451.1 aryl hydrocarbon receptor nuclear translocator isoform g

Status: VALIDATED

Source sequence(s)

AC092202, AC092203
NM_009709.4 → NP_033839.2 aryl hydrocarbon receptor nuclear translocator isoform b

See identical proteins and their annotated locations for NP_033839.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an internal coding exon, as compared to variant 1. The encoded isoform b lacks an internal segment, as compared to isoform a.

Source sequence(s)

AC092203, AK145415, CJ183661

Consensus CDS

CCDS38546.1

UniProtKB/TrEMBL

Q3U7X2, Q3ULM2

Related

ENSMUSP00000088313.6, ENSMUST00000090804.12

Conserved Domains (5) summary

smart00091
Location:151 → 215

PAS; PAS domain

cd00130
Location:347 → 443

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00010
Location:76 → 128

HLH; Helix-loop-helix DNA-binding domain

pfam00989
Location:148 → 254

PAS; PAS fold

pfam14598
Location:347 → 447

PAS_11; PAS domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

95341674..95404551

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500933.4 → XP_006500996.1 aryl hydrocarbon receptor nuclear translocator isoform X5

Conserved Domains (3) summary

smart00091
Location:362 → 415

PAS; PAS domain

pfam00989
Location:163 → 269

PAS; PAS fold

cd18947
Location:86 → 150

bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
XM_030252391.1 → XP_030108251.1 aryl hydrocarbon receptor nuclear translocator isoform X3

UniProtKB/TrEMBL

Q5DTR2

Conserved Domains (3) summary

pfam00989
Location:97 → 203

PAS; PAS fold

pfam14598
Location:296 → 396

PAS_11; PAS domain

cd18947
Location:20 → 84

bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins
XM_030252392.1 → XP_030108252.1 aryl hydrocarbon receptor nuclear translocator isoform X4

UniProtKB/TrEMBL

Q5DTR2

Conserved Domains (3) summary

pfam00989
Location:59 → 165

PAS; PAS fold

pfam14598
Location:258 → 358

PAS_11; PAS domain

cl00081
Location:1 → 46

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
XM_030252393.1 → XP_030108253.1 aryl hydrocarbon receptor nuclear translocator isoform X6

UniProtKB/TrEMBL

Q3U7X2

Conserved Domains (4) summary

pfam00989
Location:161 → 267

PAS; PAS fold

pfam10428
Location:562 → 703

SOG2; RAM signalling pathway protein

pfam14598
Location:360 → 460

PAS_11; PAS domain

cd18947
Location:84 → 148

bHLH-PAS_ARNT; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator (ARNT) and similar proteins